Description
Valium (Diazepam) 10mg
Generic Name: Diazepam
Brand Name: Valium
Drug Class: Benzodiazepine
Controlled Substance Schedule: Schedule IV (U.S.)
Indications:
Valium (diazepam) is a long-acting benzodiazepine indicated for the treatment of:
- Anxiety disorders
- Acute alcohol withdrawal symptoms
- Muscle spasms
- Seizure disorders (adjunctive therapy)
- Status epilepticus (IV/rectal form)
- Preoperative sedation (as an anxiolytic)
Mechanism of Action:
Diazepam enhances the effect of the inhibitory neurotransmitter GABA (gamma-aminobutyric acid) by binding to GABA-A receptors in the CNS. This results in sedative, anxiolytic, muscle relaxant, anticonvulsant, and amnestic effects, Buy Valium with best quality.
Dosage and Administration:
- Valium 10mg is among the higher strengths available (others include 2mg and 5mg tablets)
- For anxiety: 2–10 mg orally, 2 to 4 times daily depending on severity.
- For muscle spasms or alcohol withdrawal: typically 5–10 mg, 3 to 4 times daily
- Dosage should be individualized based on age, condition, and response, Buy Valium with best quality.
Pharmacokinetics:
- Onset of action: ~15–60 minutes (oral)
- Half-life: 20–70 hours (may be longer in elderly or liver-impaired patients)
- Active metabolites: Includes desmethyldiazepam (contributes to long duration of effect)
- Excretion: Primarily renal
Adverse Effects:
Common:
- Drowsiness
- Fatigue
- Muscle weakness
- Ataxia (loss of coordination)
- Impaired cognitive function
Contraindications:
- Severe respiratory insufficiency
- Severe hepatic impairment
- Sleep apnea syndrome
- Myasthenia gravis
- Known hypersensitivity to diazepam or other benzodiazepines
Warnings and Precautions:
- High risk of dependence with long-term or high-dose use
- Withdrawal can cause serious symptoms (e.g., seizures, tremors, agitation)
- Increased sensitivity in elderly patients — fall risk, cognitive impairment
- Avoid alcohol or opioids concurrently due to the risk of profound sedation and respiratory depression.
- Gradual tapering is essential after prolonged use.
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